What is Resveratrol?

Resveratrol is a natural polyphenol found in various plants, particularly in grapes, red wine, and berries. In skincare, resveratrol demonstrates potent anti-aging properties due to its antioxidant activity, neutralizing free radicals and protecting against oxidative stress. It helps to minimize the appearance of wrinkles, improve skin elasticity, and enhance collagen production. Additionally, resveratrol has been shown to promote skin repair, reduce inflammation, and protect against UV-induced damage, contributing to a more youthful complexion.

Information

Resveratrol

What are the benefits of Resveratrol for my hair?

Resveratrol is a polyphenolic compound found in various plants, including grapes, berries, and peanuts. While its primary health benefits are often associated with cardiovascular health and anti-aging properties, resveratrol may also offer several potential benefits for hair health:

Antioxidant Protection: Resveratrol is a potent antioxidant that helps neutralize free radicals, which can damage hair follicles and lead to hair loss or thinning. By reducing oxidative stress, resveratrol helps maintain a healthy scalp environment conducive to optimal hair growth.

Anti-inflammatory Properties: Resveratrol possesses anti-inflammatory properties that can help soothe and calm an irritated scalp. Inflammation of the scalp can disrupt the hair growth cycle and contribute to hair loss or thinning. Resveratrol's anti-inflammatory effects may help alleviate scalp conditions and promote healthier hair growth.

Stimulates Hair Growth: Some research suggests that resveratrol may help stimulate hair follicles and promote the growth of new hair. While more studies are needed to fully understand its mechanisms, resveratrol's ability to enhance blood circulation and promote cellular regeneration may contribute to its hair growth-promoting effects.

Inhibits DHT Production: Resveratrol has been shown to inhibit the activity of 5-alpha-reductase, an enzyme that converts testosterone into dihydrotestosterone (DHT). Excessive levels of DHT can contribute to hair loss and thinning in both men and women. By reducing DHT levels, resveratrol may help prevent hair loss and promote hair retention.

Protects Against UV Damage: Resveratrol's antioxidant properties help protect the hair and scalp from damage caused by UV radiation. UV exposure can lead to dryness, brittleness, and damage to the hair shaft, which can compromise hair health. By shielding the hair from UV damage, resveratrol helps maintain hair integrity and vitality.

Supports Scalp Health: Resveratrol's antioxidant and anti-inflammatory properties help maintain a healthy scalp environment by reducing oxidative stress and inflammation. Ahealthy scalp is essential for optimal hair growth and can help prevent scalp conditions such as dandruff and itching.

Resveratrol’s antioxidant, anti-inflammatory, DHT-blocking properties and stimulatory effects make it a promising compound for supporting overall scalp and hair health. Incorporating resveratrol-rich foods such as grapes, berries, and peanuts into your diet may provide some benefits for hair health. Additionally, topical treatments containing resveratrol may offer targeted support for scalp and hair conditions

Is Resveratrol Safe?

Resveratrol is safe on the hair and scalp when used at the recommended levels.

Is Resveratrol organic?

Resveratrol is an organic, natural, vitamin found in many plants and vegetables.

References

Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2012). Administration of resveratrol: What formulation solutions to bioavailability limitations? Journal of Controlled Release, 158(2), 182–193. https://doi.org/10.1016/j.jconrel.2011.09.083

Baxter, R. A. (2008). Anti-aging properties of resveratrol: Review and report of a potent new antioxidant skin care formulation. Journal of Cosmetic Dermatology, 7(1), 2–7. https://doi.org/10.1111/j.1473-2165.2008.00354.x

Chedea, V. S., Vicaş, S. I., Sticozzi, C., Pessina, F., Frosini, M., Maioli, E., & Valacchi, G. (2017). Resveratrol: from diet to topical usage. Food & Function, 8(11), 3879–3892. https://doi.org/10.1039/C7FO01086A

Chen, M. L., Li, J., Xiao, W. R., Sun, L., Tang, H., Wang, L., Wu, L. Y., Chen, X., & Xie, H. F. (2006). Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 31(5), 635–639. https://europepmc.org/article/med/17062920

Choi, S. J., & McClements, D. J. (2020). Nanoemulsions as delivery systems for lipophilic nutraceuticals: strategies for improving their formulation, stability, functionality and bioavailability. Food Science and Biotechnology, 29(2), 149–168. https://doi.org/10.1007/s10068-019-00731-4

Cottart, C. H., Nivet-Antoine, V., Laguillier-Morizot, C., & Beaudeux, J. L. (2010). Resveratrol bioavailability and toxicity in humans. Molecular Nutrition & Food Research, 54(1), 7–16. https://doi.org/10.1002/MNFR.200900437

Csekes, E., & Račková, L. (2021). Skin Aging, Cellular Senescence and Natural Polyphenols. International Journal of Molecular Sciences, 22(23). https://doi.org/10.3390/ijms222312641

Cui, B., Wang, Y., Jin, J., Yang, Z., Guo, R., Li, X., Yang, L., & Li, Z. (2022). Resveratrol Treats UVB-Induced Photoaging by Anti-MMP Expression, through Anti-Inflammatory, Antioxidant, and Antiapoptotic Properties, and Treats Photoaging by Upregulating VEGF-B Expression. Oxidative Medicine and Cellular Longevity, 2022. https://doi.org/10.1155/2022/6037303

Farris, P., Krutmann, J., Li, Y.-H., McDaniel, D., Krol, Y., Farris, P., Krutmann, J., Li, Y.-H.,McDaniel, D., & Krol, Y. (2013). Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin. Journal of Drugs in Dermatology : JDD, 12(12), 1389–1394. http://www.ncbi.nlm.nih.gov/pubmed/24301240

Gambini, J., Inglés, M., Olaso, G., Lopez-Grueso, R., Bonet-Costa, V., Gimeno-Mallench, L., Mas-Bargues, C., Abdelaziz, K. M., Gomez-Cabrera, M. C., Vina, J., & Borras, C. (2015). Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans. Oxidative Medicine and Cellular Longevity, 2015, 13. https://doi.org/10.1155/2015/837042

Ginés, C., Cuesta, S., Kireev, R., García, C., Rancan, L., Paredes, S. D., Vara, E., & Tresguerres, J. A. F. (2017). Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice. Experimental Gerontology, 90, 61–70. https://doi.org/10.1016/J.EXGER.2017.01.021

Gugleva, V., Zasheva, S., Hristova, M., & Andonova, V. (2020). Topical use of resveratrol: technological aspects. Pharmacia 67(2): 89-94, 67(2), 89–94. https://doi.org/10.3897/PHARMACIA.67.E48472

Hecker, A., Schellnegger, M., Hofmann, E., Luze, H., Nischwitz, S. P., Kamolz, L. P., & Kotzbeck, P. (2022). The impact of resveratrol on skin wound healing, scarring, and aging. International Wound Journal, 19(1), 9–28. https://doi.org/10.1111/iwj.13601

Intagliata, S., Modica, M. N., Santagati, L. M., & Montenegro, L. (2019). Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update. Antioxidants, 8(8). https://doi.org/10.3390/ANTIOX8080244

Juškaitė, V., Ramanauskienė, K., & Briedis, V. (2015). Design and Formulation of Optimized Microemulsions for Dermal Delivery of Resveratrol. Evidence-Based Complementary and Alternative Medicine, 2015, 1–10. https://doi.org/10.1155/2015/540916

Koushki, M., Amiri-Dashatan, N., Ahmadi, N., Abbaszadeh, H.-A., & Rezaei-Tavirani, M. (2018). Resveratrol: A miraculous natural compound for diseases treatment. Food Science & Nutrition, 6(8), 2473–2490. https://doi.org/10.1002/fsn3.855


Li, C., Wang, Z., Lei, H., & Zhang, D. (2023). Recent progress in nanotechnology-based drug carriers for resveratrol delivery. Drug Delivery, 30(1). https://doi.org/10.1080/10717544.2023.2174206

Lorencini, M. M., Brohen, C. A., Dieamant, G. C., Zanchin, N. I. T., Maibach, H. I., Association for the Advancement of Aging Research., M., Brohem, C. A., Dieamant, G. C., Zanchin, N. I. T., & Maibach, H. I. (2014). Active ingredients against human epidermal aging. Ageing Research Reviews, 15, 100–115. https://doi.org/10.1016/J.ARR.2014.03.002

Mascarenhas-Melo, F., Araújo, A. R. T. S., Rodrigues, M., Mathur, A., Gonçalves, M. B. S., Tanwar, K., Heidarizadeh, F., Nejaddehbashi, F., Rahdar, A., Mazzola, P. G., Veiga, F., & Paiva-Santos, A. C. (2023). Dermatological Bioactivities of Resveratrol and Nanotechnology Strategies to Boost Its Efficacy An Updated Review. Journal of Cosmetic and Laser Therapy, 10(3), 68. https://doi.org/10.3390/COSMETICS10030068

Nastiti, C. M. R. R., Ponto, T., Mohammed, Y., Roberts, M. S., & Benson, H. A. E. (2020). Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol. Pharmaceutics, 12(2). https://doi.org/10.3390/PHARMACEUTICS12020108

Ndiaye, M., Philippe, C., Ahmad, N., Mukhtar, H., & Ahmad, N. (2011). The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges. Archives of Biochemistry and Biophysics, 508(2), 164–170. https://doi.org/10.1016/J.ABB.2010.12.030

Orallo, F. (2008). Trans-Resveratrol: A Magical Elixir of Eternal Youth? Current Medicinal Chemistry, 15(19), 1887–1898. https://doi.org/10.2174/092986708785132951

Ratz-Łyko, A., & Arct, J. (2019). Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, 21(2), 84–90. https://doi.org/10.1080/14764172.2018.1469767

Shetty, A. K., Kodali, M., Upadhya, R., & Madhu, L. N. (2018). Emerging Anti-Aging Strategies - Scientific Basis and Efficacy. Aging and Disease, 9(6), 1165. https://doi.org/10.14336/AD.2018.1026

Soeur, J., Eilstein, J., Léreaux, G., Jones, C., & Marrot, L. (2015). Skin resistance to oxidative stress induced by resveratrol: From Nrf2 activation to GSH biosynthesis. Free Radical Biology & Medicine, 78, 213–223. https://doi.org/10.1016/j.freeradbiomed.2014.10.510

Tsai, M. J., Lu, I. J., Fu, Y. S., Fang, Y. P., Huang, Y. Bin, & Wu, P. C. (2016). Nanocarriers enhance the transdermal bioavailability of resveratrol: In-vitro and in-vivo study. Colloids and Surfaces B: Biointerfaces, 148, 650–656. https://doi.org/10.1016/J.COLSURFB.2016.09.045

Yutani, R., Kikuchi, T., Teraoka, R., & Kitagawa, S. (2014). Efficient delivery and distribution in skin of chlorogenic acid and resveratrol induced by microemulsion using sucrose laurate. Chemical and Pharmaceutical Bulletin, 62(3), 274–280. https://doi.org/10.1248/cpb.c13-00820

Zhang, Y., Li, Q., Niu, Y., Wei, K., Wang, X., Niu, B., & Zhang, L. (2023). Research progress on aging mechanism and drugs and the role of stem cells in anti-agingprocess. Experimental Gerontology, 179. https://doi.org/10.1016/J.EXGER.2023.112248

Zhou, D. D., Luo, M., Huang, S. Y., Saimaiti, A., Shang, A., Gan, R. Y., & Li, H. Bin. (2021). Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxidative Medicine and Cellular Longevity, 2021. https://doi.org/10.1155/2021/9932218